Nanogels for anticancer drug delivery

Steady-state and time-resolved fluorescence studies using coumarin C indicated the existence of hydrophobic domains in the ionic cores of the nanogels. Search articles by author. In present work, we explored PEG-b-poly L-glutamic acid block copolymers for development of biodegradable nanogels.

However, because these nanogels are not degradable, there is a concern for their long-term accumulation in the body that will impede the translation of such nanomedicines to practice.

Results and Discussion Design and Synthesis of Cross-linked Nanogels We extended our synthetic approach using a template-assisted procedure in order to develop biodegradable cross-linked nanogels Figure 1.

Samples were prepared in 10mM phosphate buffer at pH 7. Alike, many negatively charged hydrophobic compounds were capable to form stable water-soluble complexes with Nanogel [ 11 ].

If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. The concentration of carboxylate groups in the copolymer samples was estimated by potentiometric titration.

This degree represents the maximum theoretical amount of cross-linking that could take place, rather than the precise extent of amidation. The fabrication procedure involved a preparation of micellar templates by the self-assembly of double hydrophilic block copolymers poly ethylene glycol -b-poly methacrylic acidPEG-b-PMA with oppositely charged condensing agent e.

The nucleoside analog-using chemotherapy could be enhanced through administration of nucleoside analogs encapsulated in drug delivery system, such as liposomes, to increase cellular accumulation and cancer-specific targeting of the drugs [ 2021 ]. Animal body weight and tumor volume were monitored every second day.

In all cases the Ref. Redox-responsive cisplatin nanogels for anticancer drug delivery W. The degree of grafting of PME was determined by comparing relative signal intensities of oxymethylene protons of PEG 3.

The C fluorescenece decays were measured at different emission — nm wavelengths depending on copolymer sample. Furthermore, attachment of specific ligands to nanogel surface enables targeted drug delivery Murphy et al.

Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs

Moreover, transcellular transport of the folate-Nanogel polyplexes was found to be 4 times more effective compared to the drug alone using Caco-2 cell monolayers as an in vitro intestinal model.

All other chemicals were of reagent grade and used without further purification. Metal ions and byproducts of the cross-linking reaction were removed by exhaustive dialysis of the reaction mixtures first against 0.

We show that nanogels are enzymatically-degradable leading to accelerated drug release under simulated lysosomal acidic pH. The polyplexes have formed spontaneously by mixing solutions of FATP and Nanogels because of ionic interactions between protonated polyethylenimine PEI chains in Nanogel network with polyphosphate groups of the drug.

The data demonstrate that this carrier-based approach to delivery of cytotoxic drugs may enhance tumor specificity and significantly reduce side effects related to systemic toxicity usually observed during cancer chemotherapy.

For reproduction of material from NJC: Incorporation of cisplatin into the nanogels by polymer-metal complex formation improved drug pharmacokinetics, enhanced its antitumor efficacy, and eliminated cisplatin-mediated nephrotoxicity in a mouse model of ovarian cancer Oberoi et al.

For reproduction of material from PCCP: Our results signify the point to a potential of these biodegradable nanogels as attractive carriers for delivery of chemotherapeutics. Furthermore, the non-specific tissue biodistribution of cytotoxic drugs significantly increases their systemic toxicity.

In all cases the Ref. The reaction mixture was allowed to stir overnight at r. They can be designed to facilitate the incorporation of a variety of compounds or even particles through a combination of electrostatic, hydrophobic, and hydrogen bonding interactions.

Furthermore, we demonstrate that the nanogel-based formulation of doxorubicin is well tolerated and exhibit an improved antitumor activity compared to a free doxorubicin in an ovarian tumor xenograft mouse model. Search articles by author. Reproduced material should be attributed as follows: However, these polycationic drug carriers are far from ideal, and further developments need to reduce their toxicity, optimize circulation parameters and polyplex size [ 6 — 8 ].

TCSPC instrumental response profiles were obtained by scattering excitation light from an aqueous suspension of nondairy creamer.Title:Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery VOLUME: 23 ISSUE: 35 Author(s):Jaleh Varshosaz*, Somayeh Taymouri and Erfaneh Ghassami Affiliation:Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical.

Floxuridine-containing nucleic acid nanogels for anticancer drug delivery. Yuan Ma, a Hongxia Liu, b Quanbing Mou, a Deyue Yan, a Xinyuan Zhu a and Chuan Zhang * a Author affiliations * Corresponding authors. pH/redox/thermo-stimulative nanogels with enhanced thermosensitivity via incorporation of cationic and anionic components for anticancer drug delivery Lanlan Duan, Yifeng Wang, Yuhong Zhang, Zhiguo Wang, Yulin Li, Peixin He.

Redox-responsive cisplatin nanogels for anticancer drug delivery. Weiqi Zhang a and Ching-Hsuan Tung * a Author affiliations * Corresponding authors. Magnetic nanogels as dual triggered anticancer drug delivery: Toxicity evaluation on isolated rat liver mitochondria.

How to Cite. Molina, M., Giulbudagian, M. and Calderón, M.

Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery

(), Positively Charged Thermoresponsive Nanogels for Anticancer Drug Delivery. Macromol.

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Nanogels for anticancer drug delivery
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